Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

T Muramatsu - The journal of biochemistry, 2016 - academic.oup.com
Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to
the immunoglobulin superfamily. Basigin has isoforms; the common form (basigin or basigin …

Cyclophilin–CD147 interactions: a new target for anti-inflammatory therapeutics

V Yurchenko, S Constant… - Clinical & …, 2010 - academic.oup.com
CD147 is a widely expressed plasma membrane protein that has been implicated in a
variety of physiological and pathological activities. It is best known for its ability to function as …

The glia-neuron lactate shuttle and elevated ROS promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE/D

L Liu, KR MacKenzie, N Putluri, M Maletić-Savatić… - Cell metabolism, 2017 - cell.com
Elevated reactive oxygen species (ROS) induce the formation of lipids in neurons that are
transferred to glia, where they form lipid droplets (LDs). We show that glial and neuronal …

CD147 immunoglobulin superfamily receptor function and role in pathology

KT Iacono, AL Brown, MI Greene, SJ Saouaf - Experimental and molecular …, 2007 - Elsevier
The immunoglobulin superfamily member CD147 plays an important role in fetal, neuronal,
lymphocyte and extracellular matrix development. Here we review the current understanding …

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

GD Grass, BP Toole - Bioscience Reports, 2016 - portlandpress.com
Matrix metalloproteinases (MMPs) comprise a family of 23 zinc-dependent enzymes
involved in various pathologic and physiologic processes. In cancer, MMPs contribute to …

Cancer-related issues of CD147

UH Weidle, W Scheuer, D Eggle… - Cancer genomics & …, 2010 - cgp.iiarjournals.org
CD147 is involved in many physiological functions, such as lymphocyte responsiveness,
spermatogenesis, implantation, fertilization and neurological functions at early stages of …

The functional organisation of glia in the adult brain of Drosophila and other insects

TN Edwards, IA Meinertzhagen - Progress in neurobiology, 2010 - Elsevier
This review annotates and categorises the glia of adult Drosophila and other model insects
and analyses the developmental origins of these in the Drosophila optic lobe. The functions …

CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models

W Schneiderhan, M Scheler, KH Holzmann, M Marx… - Gut, 2009 - gut.bmj.com
Background: CD147 (basigin, EMMPRIN) is a multifunctional, highly conserved glycoprotein
enriched in pancreatic ductal adenocarcinomas (PDACs) which is associated with poor …

Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage

Y Liu, Y Mu, Z Li, VW Yong, M Xue - Frontiers in Immunology, 2022 - frontiersin.org
Increasing evidence from preclinical and clinical studies link neuroinflammation to
secondary brain injury after stroke, which includes brain ischemia and intracerebral …

Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy

HR Shcherbata, AS Yatsenko, L Patterson… - The EMBO …, 2007 - embopress.org
Perturbation in the Dystroglycan (Dg)–Dystrophin (Dys) complex results in muscular
dystrophies and brain abnormalities in human. Here we report that Drosophila is an …