The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …

The environmental and metabolic pressures in the tumor microenvironment (TME) play a
key role in molding tumor development by impacting the stromal and immune cell fractions …

Incomplete delivery to the target cells is an obstacle for successful gene therapy
approaches. Here we show unexpected effects of incomplete targeting, by demonstrating …

Activation of the PTEN–PI3K–mTORC1 pathway consolidates metabolic programs that
sustain cancer cell growth and proliferation,. Here we show that mechanistic target of …

Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to
maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of …

Innate and adaptive immune cells patrol and survey throughout the human body and
sometimes reside in the tumor microenvironment (TME) with a variety of cell types and …

To form new blood vessels (angiogenesis), endothelial cells (ECs) must be activated and
acquire highly migratory and proliferative phenotypes. However, the molecular mechanisms …