Despite several decades of intense research focused on understanding function (s) and
disease-associated malfunction of p53, there is no sign of any “mid-life crisis” in this rapidly …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Accurate replication of DNA requires stringent regulation to ensure genome integrity. In
human cells, thousands of origins of replication are coordinately activated during S phase …

The proliferative activity of tumour cells represents an important prognostic marker in the
diagnosis of cancer. One of the methods for assessing the proliferative activity of cells is the …

Following DNA damage caused by exogenous sources, such as ionizing radiation, the
tumour suppressor p53 mediates cell cycle arrest via expression of the CDK inhibitor, p21 …

Lipids are key macromolecules that perform a multitude of biological functions ranging from
maintaining structural integrity of membranes, energy storage, to signaling molecules …

Proliferating cell nuclear antigen (PCNA) plays critical roles in many aspects of DNA
replication and replication-associated processes, including translesion synthesis, error-free …

Background PCNA (proliferating cell nuclear antigen) has been found in the nuclei of yeast,
plant and animal cells that undergo cell division, suggesting a function in cell cycle …

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic
information, mechanisms to ensure genome integrity, and faithful transmission of the …