Cancer is considered as one of the most serious health problems today. The discovery of
nitrogen mustard as an alkylating agent in 1942, opened a new era in the cancer …

Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of
carcinogens that are formed during the combustion of tobacco or during the high …

The association between glutathione S-transferase (GST) activity as measured by 1-chloro-
2, 4-dinitrobenzene (CDNB) conjugation and genotype at exon 5 and exon 6 of the human …

The glutathione transferases, a family of multifunctional proteins, catalyze the glutathione
conjugation reaction with electrophilic compounds biotransformed from xenobiotics …

Background: Members of the glutathione S-transferase (GST) superfamily are important in
cellular defense mechanisms. These enzymes attach reduced glutathione to electrophilic …

Drug-metabolizing enzymes are called mixed-function oxidase or monooxygenase and
containing many enzymes including cytochrome P450, cytochrome b5, and NADPH …

The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S …

After our serum metabonomic study of colorectal cancer (CRC) patients recently published
in J. Proteome Res., we profiled urine metabolites from the same group of CRC patients …

Lactic acidosis is a feature of solid tumors and plays fundamental role (s) rendering cancer
cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox …

Purpose The objective is to investigate whether polymorphisms with putative influence on
fluorouracil/oxaliplatin activity are associated with clinical outcomes of patients with …