Rethinking clinical trials in restless legs syndrome: A roadmap

GB Diego, B Jed, F Stephany, H Birgit, M Mauro… - Sleep medicine …, 2024 - Elsevier
The number of large clinical trials of restless legs syndrome (RLS) have decreased in recent
years, this coincides with reduced interest in developing and testing novel pharmaceuticals …

Complementary and alternative therapies for restless legs syndrome: an evidence-based systematic review

XM Xu, Y Liu, SY Jia, MX Dong, D Cao, YD Wei - Sleep medicine reviews, 2018 - Elsevier
Restless legs syndrome (RLS) is defined as an irresistible urge to move the legs, which is
usually accompanied by paresthesias or dysesthesias at least twice weekly, and affects 2 …

Prevalence of restless legs syndrome in maintenance hemodialysis patients: A systematic review and meta-analysis

Y Liu, Q Du, Y Jiang - Sleep Medicine, 2023 - Elsevier
Background Restless legs syndrome is associated with quality of life and risk of death in
maintenance hemodialysis patients. Although relevant meta-analyses have been …

The effect of chrono-nutritional manipulation of carbohydrate intake on sleep macrostructure: A randomized controlled trial

A Vlahoyiannis, E Andreou, P Bargiotas, G Aphamis… - Clinical Nutrition, 2024 - Elsevier
Background & aims Over the years, there is a rapid increase in the prevalence of inadequate
sleep and its detrimental consequences. Yet, the impact of prolonged nutritional …

Short-term effects of massage with olive oil on the severity of uremic restless legs syndrome: a double-blind placebo-controlled trial

M Nasiri, M Abbasi, ZY Khosroabadi, H Saghafi… - … Therapies in Medicine, 2019 - Elsevier
Background Although the efficacy of olive oil massage has been established for different
disorders, no studies have yet focused on the effect of olive oil massage on restless legs …

Itch and ache on dialysis: new approaches to manage uremic pruritus and restless legs

S Arzhan, ME Roumelioti, ML Unruh - Blood Purification, 2020 - karger.com
Background: Uremic pruritus (UP) and restless legs syndrome (RLS) are highly prevalent
complaints among patients with end-stage renal disease (ESRD) undergoing chronic …

Prevalence and risk factors of restless legs syndrome in hemodialysis patients

LY Zhang, XY Ma, J Lin, WH Liu, W Guo… - Nature and science of …, 2020 - Taylor & Francis
Objective The current study aimed to investigate the prevalence and risk factors of restless
legs syndrome (RLS) in patients undergoing hemodialysis, as well as the mortality and risks …

Long-term intradialytic hybrid exercise training on fatigue symptoms in patients receiving hemodialysis therapy

SS Grigoriou, AA Krase, C Karatzaferi… - … Urology and Nephrology, 2021 - Springer
Purpose Hemodialysis (HD) patients suffer from generalized weakness, exercise intolerance
and muscle atrophy, all leading to generalized fatigue and lack of energy. HD patients …

Treating symptoms to improve the quality of life in patients on chronic hemodialysis

M Bossola, G Pepe, A Picca, R Calvani… - International Urology and …, 2019 - Springer
Health-related quality of life (HRQOL) in patients on chronic hemodialysis has not improved
significantly in the last 20 years. This is largely due to their substantial symptom burden …

Quality of sleep in CKD patients on chronic hemodialysis and the effect of dialysis shift

N Anwar, SN Mahmud - Journal of the College of Physicians and …, 2018 - go.gale.com
Objective: To determine the frequency of poor sleep quality in chronic kidney disease (CKD)
patients on chronic haemodialysis and compare the quality of sleep amongst patients …