Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets
Deconvolution of cell mixtures in “bulk” transcriptomic samples from homogenate human
tissue is important for understanding disease pathologies. However, several experimental …
tissue is important for understanding disease pathologies. However, several experimental …
The interaction between ageing and Alzheimer's disease: insights from the hallmarks of ageing
Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …
changes in both intracellular and extracellular microenvironments that affect the entire body …
BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer's disease (AD).
Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 …
Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 …
Single cell transcriptomes and multiscale networks from persons with and without Alzheimer's disease
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
study of Alzheimer's disease (AD). Integration with complementary multiomics data such as …
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease
Parkinson's disease (PD) is characterized pathologically by the loss of dopaminergic (DA)
neurons in the substantia nigra (SN). Whether cell types beyond DA neurons in the SN show …
neurons in the substantia nigra (SN). Whether cell types beyond DA neurons in the SN show …
Viral involvement in Alzheimer's disease
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …
Spatially resolved transcriptomics technology facilitates cancer research
Q Wang, Y Zhi, M Zi, Y Mo, Y Wang, Q Liao… - Advanced …, 2023 - Wiley Online Library
Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor
occurrence and development for its ability to study gene expression at the individual cell …
occurrence and development for its ability to study gene expression at the individual cell …
BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides
Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a
cascade of pathological changes in Alzheimer's disease (AD), and inhibiting BACE1, which …
cascade of pathological changes in Alzheimer's disease (AD), and inhibiting BACE1, which …
Alzheimer's Disease Detection Using Deep Learning on Neuroimaging: A Systematic Review
Alzheimer's disease (AD) is a pressing global issue, demanding effective diagnostic
approaches. This systematic review surveys the recent literature (2018 onwards) to …
approaches. This systematic review surveys the recent literature (2018 onwards) to …
Unraveling the intercellular communication disruption and key pathways in Alzheimer's disease: an integrative study of single-nucleus transcriptomes and genetic …
Background Recently, single-nucleus RNA-seq (snRNA-seq) analyses have revealed
important cellular and functional features of Alzheimer's disease (AD), a prevalent …
important cellular and functional features of Alzheimer's disease (AD), a prevalent …