A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

P Godoy, NJ Hewitt, U Albrecht, ME Andersen… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

In vivo delivery of miRNAs for cancer therapy: challenges and strategies

Y Chen, DY Gao, L Huang - Advanced drug delivery reviews, 2015 - Elsevier
Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

MicroRNA replacement therapy in cancer

H Mollaei, R Safaralizadeh… - Journal of cellular …, 2019 - Wiley Online Library
Despite the recent progress in cancer management approaches, the mortality rate of cancer
is still growing and there are lots of challenges in the clinics in terms of novel therapeutics …

Retracted: Mettl14 suppresses crc progression Via regulating N6-Methyladenosine-Dependent primary mir-375 processing

X Chen, M Xu, X Xu, K Zeng, X Liu, L Sun, B Pan, B He… - Molecular Therapy, 2020 - cell.com
Epigenetic alterations contributed to human carcinogenesis immensely. N6-
methyladenosine (m6A) is one of the most preventive and abundant modifications on RNA …

Gold nanoparticles: Synthesis, physiochemical properties and therapeutic applications in cancer

XY Liu, JQ Wang, CR Ashby Jr, L Zeng, YF Fan… - Drug discovery today, 2021 - Elsevier
Highlights•Gold nanoparticles (AuNPs) have been utilized in the treatment of various types
of cancer.•AuNPs have excellent photochemical and surface properties.•The properties of …

New concepts in cancer biomarkers: circulating miRNAs in liquid biopsies

E Larrea, C Sole, L Manterola, I Goicoechea… - International journal of …, 2016 - mdpi.com
The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer

H Tang, X Huang, J Wang, L Yang, Y Kong, G Gao… - Molecular cancer, 2019 - Springer
Background Increasing studies has found that circular RNAs (circRNAs) play vital roles in
cancer progression. But the expression profile and function of circRNAs in triple-negative …

MicroRNAs in the pathogenesis of hepatocellular carcinoma: a review

A Morishita, K Oura, T Tadokoro, K Fujita, J Tani… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most frequently occurring
cancers, and the prognosis for late-stage HCC remains poor. A better understanding of the …

Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnostics

N Yang, NR Ekanem, CA Sakyi, SD Ray - Advanced drug delivery reviews, 2015 - Elsevier
Hepatocellular carcinoma (HCC) remains one of the most lethal forms of cancer in the world.
In this arena, utilities of microRNA (miRNA) as a sophisticated tool, in therapeutics and …