Sepsis accounts for nearly 700 000 deaths in Europe annually and is caused by an
overwhelming host response to infection resulting in organ failure. The endothelium is an …

In the majority of patients with systemic inflammatory conditions, some degree of activation
of coagulation is present. Increasing evidence points to an extensive cross‐talk between …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the first of a 2-part review …

Thrombotic thrombocytopenic purpura (TTP) is a life-threatening systemic illness of abrupt
onset and unknown cause. Proteolysis of the blood-clotting protein von Willebrand factor …

Background Thrombotic thrombocytopenic purpura is a potentially fatal disease
characterized by widespread platelet thrombi in the microcirculation. In the normal …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic
purpura. The term thrombotic microangiopathy (TMA) defines a lesion of vessel wall …

Endothelial cells throughout the body are heterogeneous, and this is tightly linked to the
specific functions of organs and tissues. Heterogeneity is already determined from …

Hemostasis is a physiologic mechanism that maintains blood in a fluid state within the
circulation. The coagulation of blood is mediated by cellular components and soluble …