Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking,
since immune cells are able to intimately regulate vessel formation and function. Here we …

Many herbal medications are used to treat diseases but while they are often efficacious, their
safety is rarely considered by physicians or users. One particular safety concern is the risk of …

Different topical agents have been used to accelerate wound healing. The purpose of this
study is to compare the safety and efficacy of topical application of the extract of Hypericum …

Diabetes mellitus is a very common chronic disease with progressively increasing
prevalence. Besides the well-known autoimmune and inflammatory pathogenesis of type 1 …

Abstract Hypericum perforatum L.(Clusiaceae), commonly known as St. John's wort, has a
rich historical background as one of the oldest and most widely studied herbal medicines …

The acylphloroglucinol hyperforin (Hyp) from St. John's wort possesses anti-inflammatory
and anti-carcinogenic properties which were ascribed among others to the inhibition of 5 …

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit prostanoid formation and represent
prevalent therapeutics for treatment of inflammatory disorders. However, NSAIDs are …

Zingiber officinale Roscoe, popular name ginger, is grown naturally in many parts of the
world, including Brazil. Ginger is used in pharmaceutical, cosmetic, and food and beverage …

Bicyclic polyprenylated acylphloroglucinols (BPAPs), the principal bioactive benzophenone
products isolated from plants of genera Garcinia and Hypericum, have attracted noticeable …