[HTML][HTML] The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases
JM Choi, ALM Bothwell - Molecules and cells, 2012 - Elsevier
Members of the nuclear receptor superfamily function as transcription factors involved in
innate and adaptive immunity as well as lipid metabolism. These highly conserved proteins …
innate and adaptive immunity as well as lipid metabolism. These highly conserved proteins …
[HTML][HTML] Peroxisome proliferator-activated receptors and the hallmarks of cancer
N Wagner, KD Wagner - Cells, 2022 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors
upon the binding of physiological or pharmacological ligands and heterodimerization with …
upon the binding of physiological or pharmacological ligands and heterodimerization with …
[HTML][HTML] Translation attenuation through eIF2α phosphorylation prevents oxidative stress and maintains the differentiated state in β cells
SH Back, D Scheuner, J Han, B Song, M Ribick… - Cell metabolism, 2009 - cell.com
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA
translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on …
translation through PERK-mediated phosphorylation of eukaryotic initiation factor 2 on …
Functional characterization of BTKC481S mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors
The Bruton tyrosine kinase (BTK) inhibitor, ibrutinib, has produced remarkable clinical
response in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. We previously …
response in chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. We previously …
Suppression of pro-inflammatory adhesion molecules by PPAR-δ in human vascular endothelial cells
Objective—Endothelial activation is implicated in atherogenesis and diabetes. The role of
peroxisome proliferator-activated receptor-δ (PPAR-δ) in endothelial activation remains …
peroxisome proliferator-activated receptor-δ (PPAR-δ) in endothelial activation remains …
[HTML][HTML] Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2
Aims Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate
the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective …
the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective …
[HTML][HTML] Sex-specific regulation of immune responses by PPARs
The prevalence of autoimmune, infectious and metabolic diseases is different for men and
women owing to the respective ability of their immune systems to respond to self and foreign …
women owing to the respective ability of their immune systems to respond to self and foreign …
SYK inhibition and response prediction in diffuse large B-cell lymphoma
S Cheng, G Coffey, XH Zhang… - Blood, The Journal …, 2011 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin
lymphoma, and the role of SYK in its pathogenesis is not completely understood. Using …
lymphoma, and the role of SYK in its pathogenesis is not completely understood. Using …
Intra‐and inter‐chromosomal interactions correlate with CTCF binding genome wide
A prime goal in systems biology is the comprehensive use of existing high‐throughput
genomic datasets to gain a better understanding of chromatin organization and genome …
genomic datasets to gain a better understanding of chromatin organization and genome …
Methyl pyruvate rescues mitochondrial damage caused by SIGMAR1 mutation related to amyotrophic lateral sclerosis
Background Amyotrophic lateral sclerosis (ALS) is a disease caused by motor neuron
degeneration. Recently, a novel SIGMAR1 gene variant (p. E102Q) was discovered in some …
degeneration. Recently, a novel SIGMAR1 gene variant (p. E102Q) was discovered in some …