Reactive oxygen species (ROS) are important cellular signalling molecules but sudden
changes in redox balance can be deleterious to cells and lethal to the whole organism. ROS …

Suspended animation for deep-space travelers is moving out of the realm of science fiction.
Two approaches are considered: the first elaborates the current medical practice of …

Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce
ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney …

Mammalian hibernators endure severe and prolonged hypothermia that is lethal to non-
hibernators, including humans and mice. The mechanisms responsible for the cold …

Ischemic stroke (IS) is a detrimental neurological disease with limited treatment options.
Astragaloside IV (As‐IV) was a promising bioactive constituent in the treatment of IS …

Background Endometrial cancer (EC) poses a serious threat to women's health.
Radiotherapy has been widely used for EC treatment. However, the mechanism of FIRRE in …

Neuronal injury during acute hypoxia, ischemia, and following reperfusion are partially
attributable to oxidative damage caused by deleterious fluctuations of reactive oxygen …

Hibernators show superior resistance to ischemia and hypothermia, also outside the
hibernation season. Therefore, hibernation is a promising strategy to decrease cellular …

In awake and behaving mammals (with core and brain temperatures at~ 37° C),
hippocampal neurons have anatomical and physiological properties that support formation …

Mitochondrial failure is recognized to play an important role in a variety of diseases. We
previously showed hibernating species to have cell-autonomous protective mechanisms to …