The majority of potentially preventable deaths after trauma are related to hemorrhage and
occur early after injury, with the largest number of deaths occurring before hospital arrival …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Background Plasma is integral to haemostatic resuscitation after injury, but the timing of
administration remains controversial. Anticipating approval of lyophilised plasma by the US …

Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background The resuscitation of severely injured bleeding patients has evolved into a multi-
modal strategy termed damage control resuscitation (DCR). This guideline evaluates …

Importance Prehospital blood product transfusion in trauma care remains controversial due
to poor-quality evidence and cost. Sequential expansion of blood transfusion capability after …

Importance Although the Afghanistan and Iraq conflicts have the lowest US case-fatality
rates in history, no comprehensive assessment of combat casualty care statistics, major …

Objective To relate in-hospital mortality to early transfusion of plasma and/or platelets and to
time-varying plasma: red blood cell (RBC) and platelet: RBC ratios. Design Prospective …

Introduction Evidence-based recommendations are needed to guide the acute management
of the bleeding trauma patient. When these recommendations are implemented patient …

Objectives To characterize contemporary use of tranexamic acid (TXA) in combat injury and
to assess the effect of its administration on total blood product use, thromboembolic …