Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
A Mushtaq, U Azam, S Mehreen, MM Naseer - European journal of …, 2023 - Elsevier
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D Xiao, L Lu, B Liang, Z Xiong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Synthesis, biological evaluation and action mechanism of 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone derivatives as α-glucosidase inhibitors
Q Feng, J Zhang, S Luo, Y Huang, Z Peng… - European Journal of …, 2023 - Elsevier
In our work, several 7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-phenylhydrazone
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
derivatives as α-glucosidase inhibitors (α-GIs) were synthesized and characterized by 1 H …
Synthesis, in vitro, and in silico evaluation of Indazole Schiff bases as potential α-glucosidase inhibitors
Indazole Schiff bases were synthesized 1–24 and structurally characterized by different
spectroscopic techniques such as EI-MS, HREI-MS, 1 H-and 13 C-NMR. Stereochemistry of …
spectroscopic techniques such as EI-MS, HREI-MS, 1 H-and 13 C-NMR. Stereochemistry of …
[HTML][HTML] Structural characterization and molecular docking screening of most potent 1, 2, 4-triazine sulfonamide derivatives as anti-cancer agents
One of the biggest problems facing contemporary medicine is cancer. New approaches to
therapy are required due to the difficult and prolonged treatment, the numerous adverse …
therapy are required due to the difficult and prolonged treatment, the numerous adverse …
Diphenyl-substituted triazine derivatives: synthesis, α-glucosidase inhibitory activity, kinetics and in silico studies
Background: Diabetes mellitus (DM) is a chronic disorder, considered to be a major global
health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to …
health challenge in the 21st century. α-Glucosidase enzyme is a well-known drug target to …
Design, synthesis and bio-evaluation of indolin-2-ones as potential antidiabetic agents
Background: Diabetes mellitus is a serious global health concern, and this is expected to
impact more than 300 million people by 2025. The current study focuses on identifying …
impact more than 300 million people by 2025. The current study focuses on identifying …
[HTML][HTML] Density functional theory (DFT), molecular docking, and xanthine oxidase inhibitory studies of dinaphthodiospyrol S from Diospyros kaki L
In this work, we investigated Diospyros kaki extract and an isolated compound for their
potential as xanthine oxidase (XO) inhibitors, a target enzyme involved in inflammatory …
potential as xanthine oxidase (XO) inhibitors, a target enzyme involved in inflammatory …
Design, Synthesis and biological evaluation of novel benzopyran derivatives as potential α-amylase inhibitors: An Investigation by Experimental and Computational …
A Hajlaoui, A Assel, H Lazrag, J Bouajila… - Journal of Molecular …, 2023 - Elsevier
A novel series of benzopyran derivatives 4, 5, and 6a-i was synthesized via
cyclocondensation reaction of hydrazide 3 with some electrophilic species such as 2, 4 …
cyclocondensation reaction of hydrazide 3 with some electrophilic species such as 2, 4 …