We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …

The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with
interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid …

Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is
important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but …

The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

The glymphatic system is a glial-dependent waste clearance pathway in the brain, in place
of lymphatic vessels, dedicated to drain away soluble waste proteins and metabolic …

The glymphatic system has in previous studies been shown as fundamental to clearance of
waste metabolites from the brain interstitial space, and is proposed to be instrumental in …

To what extent does the subarachnoid cerebrospinal fluid (CSF) compartment communicate
directly with the extravascular compartment of human brain tissue? Interconnection between …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …