Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Bacteria adapt to changes in their environment using a mechanism known as the two-
component regulatory system (TCS)(also called “two-component signal transduction system” …

The development of bacterial resistance to traditional antibiotics constitutes an emerging
public health issue. Promising approaches have been innovated to conquer bacterial …

The prevalence of antimicrobial-resistant pathogens significantly limited the number of
effective antibiotics available clinically, which urgently requires new drug targets to screen …

Abstract Calcium (Ca 2+) is a universal signaling ion, whose major informational role
shaped the evolution of signaling pathways, enabling cellular communications and …

Shigella is a specific enteric pathogen in humans, causing symptoms of bacterial dysentery.
The biofilm formation of S. flexneri contributes to the emergence of multidrug resistance and …

Since the discovery of penicillin in the first half of the last century, antibiotics have become
the pillars of modern medicine for fighting bacterial infections. However, pathogens resistant …

Klebsiella pneumoniae (Kp) is a globally disseminated opportunistic pathogen that can
cause life-threatening infections. It has been found as the culprit of many infection outbreaks …

Antibacterial agents that exploit new targets will be required to combat the perpetual rise of
bacterial resistance to current antibiotics. We are exploring the inhibition of histidine kinases …

The two-component signal transduction system PhoP/PhoQ is an important regulator for
stress responses and virulence in most Gram-negative bacteria, but characterization of …