L‐type calcium channels (Cav1) represent one of the three major classes (Cav1–3) of
voltage‐gated calcium channels. They were identified as the target of clinically used calcium …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Electrical remodeling of the heart takes place in response to both functional (altered
electrical activation) and structural (including heart failure and myocardial infarction) …

Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across
the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs) …

Persistent activation of the transcription factor Nuclear factor-κB (NF-κB) is central to the
pathogenesis of many inflammatory disorders, including those of the lung such as cystic …

Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and
neurodegeneration in Huntington disease (HD); however, the factors that disrupt …

Fibroblast growth factor homologous factors (FHFs, FGF11–14) bind to the C termini (CTs) of
specific voltage-gated sodium channels (VGSC) and thereby regulate their function. The …

KV channel-interacting proteins (KChIP1-4) belong to a family of Ca2+-binding EF-hand
proteins that are able to bind to the N-terminus of the KV4 channel α-subunits. KChIPs are …

Auxiliary subunits are non-conducting, modulatory components of the multi-protein ion
channel complexes that underlie normal neuronal signaling. They interact with the pore …

Calcium signalling plays a crucial role in the control of neuronal function and plasticity.
Changes in neuronal Ca 2+ concentration are detected by Ca 2+-binding proteins that can …