OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
M Roth, A Obaidat, B Hagenbuch - British journal of …, 2012 - Wiley Online Library
The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …
Impact of OATP transporters on pharmacokinetics
A Kalliokoski, M Niemi - British journal of pharmacology, 2009 - Wiley Online Library
Membrane transporters are now recognized as important determinants of the
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …
transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a …
Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake
M Niemi, MK Pasanen, PJ Neuvonen - Pharmacological reviews, 2011 - ASPET
The importance of membrane transporters for drug pharmacokinetics has been increasingly
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
recognized during the last decade. Organic anion transporting polypeptide 1B1 (OATP1B1) …
Combined angiotensin receptor antagonism and neprilysin inhibition
SA Hubers, NJ Brown - Circulation, 2016 - Am Heart Assoc
Heart failure affects≈ 5.7 million people in the United States alone. Angiotensin-converting
enzyme inhibitors, angiotensin receptor blockers, β-blockers, and aldosterone antagonists …
enzyme inhibitors, angiotensin receptor blockers, β-blockers, and aldosterone antagonists …
Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption
Organic anion transporting polypeptide (OATP) family transporters accept a number of drugs
and are increasingly being recognized as important factors in governing drug and …
and are increasingly being recognized as important factors in governing drug and …
Drug transporters in drug efficacy and toxicity
MK DeGorter, CQ Xia, JJ Yang… - Annual review of …, 2012 - annualreviews.org
Drug transporters are now widely acknowledged as important determinants governing drug
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
absorption, excretion, and, in many cases, extent of drug entry into target organs. There is …
A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists
MC Michel, C Foster, HR Brunner, L Liu - Pharmacological reviews, 2013 - ASPET
Angiotensin II type 1 receptor antagonists (ARBs) have become an important drug class in
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …
the treatment of hypertension and heart failure and the protection from diabetic nephropathy …
New era in drug interaction evaluation: US Food and Drug Administration update on CYP enzymes, transporters, and the guidance process
SM Huang, JM Strong, L Zhang… - The Journal of …, 2008 - Wiley Online Library
Predicting clinically significant drug interactions during drug development is a challenge for
the pharmaceutical industry and regulatory agencies. Since the publication of the US Food …
the pharmaceutical industry and regulatory agencies. Since the publication of the US Food …
Transporter pharmacogenetics and statin toxicity
M Niemi - Clinical Pharmacology & Therapeutics, 2010 - Wiley Online Library
Polymorphisms in transporter genes can have profound effects on statin pharmacokinetics.
In particular, a common genetic variant of organic anion–transporting polypeptide 1B1 …
In particular, a common genetic variant of organic anion–transporting polypeptide 1B1 …
Myotoxicity of statins: Mechanism of action
P du Souich, G Roederer, R Dufour - Pharmacology & therapeutics, 2017 - Elsevier
Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia;
however, they cause frequent undesirable side effects. The incidence of statin-induced …
however, they cause frequent undesirable side effects. The incidence of statin-induced …