Identification of metabolism-associated biomarkers for early and precise diagnosis of oral squamous cell carcinoma

Y Wang, X Zhang, S Wang, Z Li, X Hu, X Yang, Y Song… - Biomolecules, 2022 - mdpi.com
The 5-year survival rate for oral squamous cell carcinoma (OSCC), one of the most common
head and neck cancers, has not improved in the last 20 years. Poor prognosis of OSCC is …

[HTML][HTML] Advanced progress of spatial metabolomics in head and neck cancer research

H Zhao, C Shi, W Han, G Luo, Y Huang, Y Fu, W Lu… - Neoplasia, 2024 - Elsevier
Head and neck cancer ranks as the sixth most prevalent malignancy, constituting 5% of all
cancer cases. Its inconspicuous onset often leads to advanced stage diagnoses, prompting …

Targeting squalene epoxidase confers metabolic vulnerability and overcomes chemoresistance in HNSCC

X Zhao, B Guo, W Sun, J Yu, L Cui - Advanced Science, 2023 - Wiley Online Library
Cisplatin resistance poses a substantial hurdle in effectively treating head and neck
squamous cell carcinoma (HNSCC). Utilizing multiple tumor models and examining an …

Integrated non-targeted lipidomics and metabolomics analyses for fluctuations of neonicotinoids imidacloprid and acetamiprid on Neuro-2a cells

X Wang, J Qiu, Y Xu, G Liao, Q Jia, Y Pan, T Wang… - Environmental …, 2021 - Elsevier
Neonicotinoid insecticides are widely used for pest control. However, they are highly water-
soluble and easily ingested by organisms, posing potential health risks. In this study …

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer

CR Maier, O Hartmann, C Prieto-Garcia… - Cell Death & …, 2023 - nature.com
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that
drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides …

Chronic restraint stress promotes the tumorigenic potential of oral squamous cell carcinoma cells by reprogramming fatty acid metabolism via CXCL3 mediated Wnt/β …

F Lou, H Long, S Luo, Y Liu, J Pu, H Wang, P Ji… - Experimental …, 2023 - Elsevier
Chronic stress promotes tumor progression and may harm homeostasis of energy
metabolism by disrupting key metabolic processes. Recently, emerging evidence that …

Prognostic value of lipid metabolism‐related genes in head and neck squamous cell carcinoma

Y Xiong, Y Si, Y Feng, S Zhuo, B Cui… - Immunity, Inflammation …, 2021 - Wiley Online Library
Background Altered lipid metabolism is involved in the development of many tumors.
However, the role of dissimilar lipid metabolism in head and neck squamous cell carcinoma …

Connecting the dots: investigating the link between environmental, genetic, and epigenetic influences in metabolomic alterations in oral squamous cell carcinoma

I Gupta, F Badrzadeh, Y Tsentalovich… - Journal of Experimental & …, 2024 - Springer
Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

Lipid metabolism reprogramming in head and neck cancer

J Liang, L Li, L Li, X Zhou, Z Zhang, Y Huang… - Frontiers in …, 2023 - frontiersin.org
Lipid metabolism reprogramming is one of the most prominent metabolic anomalies in
cancer, wherein cancer cells undergo dysregulation of lipid metabolism to acquire adequate …

In vivo metabolic analysis of the anticancer effects of plasma-activated saline in three tumor animal models

M Qi, D Xu, S Wang, B Li, S Peng, Q Li, H Zhang, R Fan… - Biomedicines, 2022 - mdpi.com
In recent years, the emerging technology of cold atmospheric pressure plasma (CAP) has
grown rapidly along with the many medical applications of cold plasma (eg, cancer, skin …