Common airborne allergens (pollen, animal dander and those from fungi and insects) are
the main triggers of type I allergic disorder in the respiratory system and are associated with …

House dust mite (HDM) encloses an explosive cocktail of allergenic proteins sensitizing
hundreds of millions of people worldwide. To date, the innate cellular and molecular …

Environmental allergens that interact with the airway epithelium can activate cellular stress
pathways that lead to the release of danger signals known as alarmins. The mechanisms of …

Conjunctival epithelia cells play an important role in the development of allergic reactions.
TLR7 agonists have been shown in studies to increase the body's immunological tolerance …

According to the concept of “united airway diseases”, the airway is a single organ in which
upper and lower airway diseases are commonly comorbid. A range of inflammatory factors …

This is an exciting time to be conducting asthma research. The recent development of
targeted asthma biologics has validated the power of basic research to discover new …

Chronic rhinosinusitis (CRS) is a common chronic nasal cavity and sinus disease, affecting
a growing number of individuals worldwide. Recent advances have shifted our …

Released mitochondrial DNA (mtDNA) in cells activates cGAS-STING pathway, which
induces expression of interferon-stimulated genes (ISGs) and thereby promotes …

Lung pathogenic T helper type 2 (pTh2) cells are important drivers of allergic asthma, but
fundamental questions remain regarding their regulation and heterogeneity. The …

Asthma is the most common chronic disease of childhood and the most common
noncommunicable respiratory disease globally, presently affecting around 350 million …