Polyamines are small polycationic molecules found in almost all cells and associated with a
wide variety of physiological processes. In recent years it has become increasingly clear …

Airway epithelial cells are the first line of defense against invading microbes, and they
protect themselves through the production of carbohydrate and protein matrices …

The enzyme fructose-bisphosphate aldolase occupies a central position in glycolysis and
gluconeogenesis pathways. Beyond its housekeeping role in metabolism, fructose …

Background Prior to this study, relatively few strains of Francisella had been genome-
sequenced. Previously published Francisella genome sequences were largely restricted to …

The intracellular Gram-negative bacterium Francisella tularensis causes the disease
tularemia and is known for its ability to subvert host immune responses. Previous work from …

Ft is a facultative intracellular pathogen that infects many cell types, including neutrophils. In
previous work, we demonstrated that the type B Ft strain LVS disrupts NADPH oxidase …

Francisella tularensis is a gram-negative facultative bacterium that causes the disease
tularemia, even upon exposure to low numbers of bacteria. One critical characteristic of …

ABSTRACT “Francisella tularensis subsp. novicida” intranasal infection causes a rapid
pneumonia in mice with mortality at 4 to 6 days with a low dose of bacteria (102 bacteria) …

Abstract The bacterium Francisella tularensis (Ft) is a potential weapon of bioterrorism when
aerosolized. Macrophage infection is necessary for disease progression and efficient …

Potassium is an essential mineral nutrient required by all living cells for normal physiological
function. Therefore, maintaining intracellular potassium homeostasis during bacterial …