Role of Nrf2 in aging, Alzheimer's and other neurodegenerative diseases

M George, M Tharakan, J Culberson, AP Reddy… - Ageing Research …, 2022 - Elsevier
Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

H Xu, S Li, YS Liu - Signal Transduction and Targeted Therapy, 2022 - nature.com
Aging-induced alternations of vasculature structures, phenotypes, and functions are key in
the occurrence and development of vascular aging-related diseases. Multiple molecular and …

Polyphenols mediate neuroprotection in cerebral ischemic stroke—an update

SA Abdelsalam, K Renu, HA Zahra, BM Abdallah… - Nutrients, 2023 - mdpi.com
Stroke is one of the main causes of mortality and disability, and it is due to be included in
monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused …

Potential of nano-antioxidants and nanomedicine for recovery from neurological disorders linked to long COVID syndrome

T Akanchise, A Angelova - Antioxidants, 2023 - mdpi.com
Long-term neurological complications, persisting in patients who cannot fully recover
several months after severe SARS-CoV-2 coronavirus infection, are referred to as …

Targeted pathophysiological treatment of ischemic stroke using nanoparticle-based drug delivery system

W Liu, L Liu, H Li, Y Xie, J Bai, J Guan, H Qi… - Journal of …, 2024 - Springer
Ischemic stroke poses significant challenges in terms of mortality and disability rates
globally. A key obstacle to the successful treatment of ischemic stroke lies in the limited …

[HTML][HTML] Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

T Pant, N Uche, M Juric, J Zielonka, X Bai - Redox Biology, 2024 - Elsevier
Inflammatory diseases present a serious health challenge due to their widespread
prevalence and the severe impact on patients' lives. In the quest to alleviate the burden of …

Nanoparticle formulations of antioxidants for the management of oxidative stress in stroke: A review

S Salatin, M Farhoudi, A Farjami, S Maleki Dizaj… - Biomedicines, 2023 - mdpi.com
Stroke is currently one of the primary causes of morbidity and mortality worldwide.
Unfortunately, there has been a lack of effective stroke treatment. Therefore, novel treatment …

Tapping into Nature's Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention

V Pinilla-González, C Rojas-Solé, F Gómez-Hevia… - Foods, 2024 - mdpi.com
Numerous natural antioxidants commonly found in our daily diet have demonstrated
significant benefits for human health and various diseases by counteracting the impact of …

[HTML][HTML] Revolutionizing Neurotherapeutics: Nanocarriers Unveiling the Potential of Phytochemicals in Alzheimer's Disease

AP Kamath, PG Nayak, J John, S Mutalik… - …, 2024 - Elsevier
Neurological disorders pose a huge worldwide challenge to the healthcare system,
necessitating innovative strategies for targeted drug delivery to the central nervous system …