Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Hypoxia is an important feature of most solid tumors, conferring resistance to radiation and
many forms of chemotherapy. However, it is possible to exploit the presence of tumor …

Background Triple negative breast cancer (TNBC) is an aggressive tumor with extremely
high mortality that results from its lack of effective therapeutic targets. As an adhesion …

In tumours, hypoxia—a condition in which the demand for oxygen is higher than its
availability—is well known to be associated with reduced sensitivity to radiotherapy and …

Simple Summary The identification and validation of strategies to individualise therapy of
patients with head and neck squamous cell carcinoma require cellular and animal models …

Rationale: Hypoxic regions (habitats) within tumors are heterogeneously distributed and can
be widely variant. Hypoxic habitats are generally pan-therapy resistant. For this reason …

Despite considerable progress has been achieved in hypoxia-associated anti-tumor
therapy, the efficacy of utilizing hypoxia-activated prodrugs alone is not satisfied owing to the …

Introduction Hypoxia is an important characteristic of solid tumors. However, spatial
transcriptomics (ST) of hypoxia-associated heterogeneity is not clear. Methods This study …

Tumour hypoxia promotes poor patient outcomes, with particularly strong evidence for head
and neck squamous cell carcinoma (HNSCC). To effectively target hypoxia, therapies …

Hypoxia enhances tumor aggressiveness, thereby reducing the efficacy of anticancer
therapies. Phytomedicine, which is nowadays considered as the new panacea owing to its …