Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood
vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was …

Large, elastic arteries are composed of cells and a specialized extracellular matrix that
provides reversible elasticity and strength. Elastin is the matrix protein responsible for this …

Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …

Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Biomaterials based upon elastin and elastin-derived molecules are increasingly
investigated for their application in tissue engineering. This interest is fuelled by the …

Elastin is an important protein of the extracellular matrix of higher vertebrates, which confers
elasticity and resilience to various tissues and organs including lungs, skin, large blood …

Hypertension is a frequent condition encountered during kidney disease development and a
leading cause in its progression. Hallmark factors contributing to hypertension constitute a …

Vascular calcification or ectopic mineralization in blood vessels is an active, cell-regulated
process, increasingly recognized as a general cardiovascular risk factor. Remarkably …

Calcific aortic valve disease (CAVD) increasingly afflicts our aging population. One third of
our elderly have echocardiographic or radiological evidence of calcific aortic valve sclerosis …