Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

Several components that interact with each other to evolve a complex, and, in some cases,
unexpected behavior, represents one of the main and fascinating features of the mammalian …

Mathematical and computational models are increasingly used to help interpret biomedical
data produced by high-throughput genomics and proteomics projects. The application of …

Overwhelming evidence has shown the significant role of the tumor microenvironment (TME)
in governing the triple-negative breast cancer (TNBC) progression. Digital pathology can …

Molecular dynamics simulations have to be sufficiently long to draw reliable conclusions.
However, no method exists to prove that a simulation has converged. We suggest the …

Materials and Methods: Patient epicrisis reports obtained from the Pasteur Laboratory in the
north of Iran were used. All 175 samples have twenty features. The features are classified …

This paper is concerned with analytical investigations on the competition between cancer
cells and immune system cells. Specifically the role of the B-cells and T-cells in the evolution …

Statistical mechanics is a powerful method for understanding equilibrium thermodynamics.
An equivalent theoretical framework for nonequilibrium systems has remained elusive. The …

Abstract Excepting the Peripheral and Central Nervous Systems, the Immune System is the
most complex of somatic systems in higher animals. This complexity manifests itself at many …

The definition of artificial immunity, realized through vaccinations, is nowadays a practice
widely developed in order to eliminate cancer disease. The present paper deals with an …