Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

RING finger domain and RING finger-like ubiquitin ligases (E3s), such as U-box proteins,
constitute the vast majority of known E3s. RING-type E3s function together with ubiquitin …

The formation of the autophagosome, a landmark event in autophagy, is accomplished by
the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in …

The modification of proteins with ubiquitin chains can change their localization, activity
and/or stability. Although ubiquitylation requires the concerted action of ubiquitin-activating …

Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Following the discovery of protein modification by the small, highly conserved ubiquitin
polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function …

Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to
substrate proteins, modulates many important biological processes, including …