The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …

The identification of the presence of active signaling between astrocytes and neurons in a
process termed gliotransmission has caused a paradigm shift in our thinking about brain …

The final stage of brain development is associated with the generation and maturation of
neuronal synapses. However, the same period is also associated with a peak in synapse …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by
progressive degeneration of motor neurons leading to skeletal muscle denervation. Earlier …

Basal synaptic transmission involves the release of neurotransmitters at individual synapses
in response to a single action potential. Recent discoveries show that astrocytes modulate …

Peripheral nerves exist in a stable state in adulthood providing a rapid bidirectional
signaling system to control tissue structure and function. However, following injury …

The emergence of astroglia as an important participant of the synaptic machinery has led to
the 'tripartite synapse'hypothesis. Recent findings suggest that synaptic signaling also …

The formation of highly efficient and reliable synapses at the neuromuscular junction (NMJ)
relies on dynamic molecular interactions. Studies of the development and maturation of the …

How tissues are maintained over a lifetime and repaired following injury are fundamental
questions in biology with a disruption to these processes underlying pathologies such as …