Evidences for adult hippocampal neurogenesis in humans

EP Moreno-Jiménez, J Terreros-Roncal… - Journal of …, 2021 - Soc Neuroscience
The rodent hippocampus generates new neurons throughout life. This process, named adult
hippocampal neurogenesis (AHN), is a striking form of neural plasticity that occurs in the …

Formation and integration of new neurons in the adult hippocampus

A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

[HTML][HTML] Microglial remodeling of the extracellular matrix promotes synapse plasticity

PT Nguyen, LC Dorman, S Pan, ID Vainchtein, RT Han… - Cell, 2020 - cell.com
Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we
define a molecular interaction between neurons and microglia that drives experience …

Adult-born dentate granule cells promote hippocampal population sparsity

SB McHugh, V Lopes-dos-Santos, GP Gava… - Nature …, 2022 - nature.com
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …

Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories

T Hainmueller, M Bartos - Nature Reviews Neuroscience, 2020 - nature.com
The dentate gyrus (DG) has a key role in hippocampal memory formation. Intriguingly, DG
lesions impair many, but not all, hippocampus-dependent mnemonic functions, indicating …

The role of adult hippocampal neurogenesis in brain health and disease

T Toda, SL Parylak, SB Linker, FH Gage - Molecular psychiatry, 2019 - nature.com
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number
of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating …

Beyond the hippocampus and the SVZ: adult neurogenesis throughout the brain

MP Jurkowski, L Bettio, E K. Woo, A Patten… - Frontiers in cellular …, 2020 - frontiersin.org
Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood

C Anacker, R Hen - Nature Reviews Neuroscience, 2017 - nature.com
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Adult neurogenesis in the hippocampus: from stem cells to behavior

JT Gonçalves, ST Schafer, FH Gage - Cell, 2016 - cell.com
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

Sex differences in hippocampal cognition and neurogenesis

S Yagi, LAM Galea - Neuropsychopharmacology, 2019 - nature.com
Sex differences are reported in hippocampal plasticity, cognition, and in a number of
disorders that target the integrity of the hippocampus. For example, meta-analyses reveal …