Recent advances in defining the genetic mechanisms of disease causation and modification
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …

In this article, we review the current evidence for the cellular and molecular mechanisms of
AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using ischemic …

Mitochondrial dysfunction is considered as a key mediator in the pathogenesis of diabetic
nephropathy (DN). Therapeutic strategies targeting mitochondrial dysfunction hold …

Background Young female patients who receive chemotherapy frequently face premature
ovarian failure (POF). The therapeutic potential of stem cells in these patients has been …

The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Abstract MNNG HOS transforming gene (MET) is a class IV receptor tyrosine kinase,
expressed on the surface of epithelial cells. The interaction with the hepatocyte grow factor …

Acute kidney injury (AKI) is defined as a rapid decline in renal function and is characterized
by excessive renal inflammation and programmed death of resident cells. AKI shows high …

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied
over several decades, but was only recently recognized as a key player in mediating …

Acute kidney injury (AKI) is a major renal disease associated with high mortality rate and
increasing prevalence. Decades of research have suggested numerous chemical and …

Background: A wide variety of kidney diseases ultimately lead to tubulointerstitial damage.
The initial site of injury is usually the renal tubules, with activation of fibroblasts occurring …