The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in Microbiology, 2021 - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives

SM Gygli, S Borrell, A Trauner… - FEMS microbiology …, 2017 - academic.oup.com
Antibiotic-resistant Mycobacterium tuberculosis strains are threatening progress in
containing the global tuberculosis epidemic. Mycobacterium tuberculosis is intrinsically …

Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care

N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

Overview on mechanisms of isoniazid action and resistance in Mycobacterium tuberculosis

AN Unissa, S Subbian, LE Hanna… - Infection, Genetics and …, 2016 - Elsevier
Isoniazid (INH) is one of the most active compounds used to treat tuberculosis (TB)
worldwide. In addition, INH has been used as a prophylactic drug for individuals with latent …

[HTML][HTML] Multidrug efflux pumps in Staphylococcus aureus: an update

SS Costa, M Viveiros, L Amaral… - The open microbiology …, 2013 - ncbi.nlm.nih.gov
The emergence of infections caused by multi-or pan-resistant bacteria in the hospital or in
the community settings is an increasing health concern. Albeit there is no single resistance …

Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis

K Dheda, T Gumbo, NR Gandhi, M Murray… - The lancet Respiratory …, 2014 - thelancet.com
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery

D Bald, C Villellas, P Lu, A Koul - MBio, 2017 - Am Soc Microbiol
Drug-resistant mycobacterial infections are a serious global health challenge, leading to
high mortality and socioeconomic burdens in developing countries worldwide. New …

New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria

MJ Nasiri, M Haeili, M Ghazi, H Goudarzi… - Frontiers in …, 2017 - frontiersin.org
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …