Natural products are widely employed in our daily lives as food additives, pharmaceuticals,
nutraceuticals, and cosmetic ingredients, among others. However, their supply has often …

Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

The most common prokaryotic signal transduction mechanisms are the one-component
systems in which a single polypeptide contains both a sensory domain and a DNA-binding …

Large genetic engineering projects require more cistrons and consequently more strong and
reliable transcriptional terminators. We have measured the strengths of a library of …

Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Bacterial genes associated with a single trait are often grouped in a contiguous unit of the
genome known as a gene cluster. It is difficult to genetically manipulate many gene clusters …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …