Technology in the management of type 1 diabetes mellitus—current status and future prospects

M Tauschmann, R Hovorka - Nature Reviews Endocrinology, 2018 - nature.com
Type 1 diabetes mellitus (T1DM) represents 5–10% of diabetes cases worldwide. The
incidence of T1DM is increasing, and there is no immediate prospect of a cure. As such …

Oral delivery of insulin for treatment of diabetes: status quo, challenges and opportunities

CY Wong, J Martinez, CR Dass - Journal of Pharmacy and …, 2016 - academic.oup.com
Objectives Diabetes mellitus is characterised by progressive β-cell destruction and loss of
function, or loss of ability of tissues to respond to insulin. Daily subcutaneous insulin …

Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society

ER Seaquist, J Anderson, B Childs… - The Journal of …, 2013 - academic.oup.com
Objective: To review the evidence about the impact of hypoglycemia on patients with
diabetes that has become available since the past reviews of this subject by the American …

[PDF][PDF] ISPAD Clinical Practice Consensus Guidelines 2018: Assessment and management of hypoglycemia in children and adolescents with diabetes.

MB Abraham, TW Jones, D Naranjo, B Karges… - Pediatric diabetes, 2018 - bnsde.org
• If unexplained hypoglycemia is frequent, evaluation for unrecognized celiac and Addison's
disease should be considered (E).• Currently available technologies like CGM, automated …

Threshold-based insulin-pump interruption for reduction of hypoglycemia

RM Bergenstal, DC Klonoff, SK Garg… - … England Journal of …, 2013 - Mass Medical Soc
Background The threshold-suspend feature of sensor-augmented insulin pumps is designed
to minimize the risk of hypoglycemia by interrupting insulin delivery at a preset sensor …

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

X Hu, J Yu, C Qian, Y Lu, AR Kahkoska, Z Xie, X Jing… - ACS …, 2017 - ACS Publications
A self-regulated “smart” insulin administration system would be highly desirable for diabetes
management. Here, a glucose-responsive insulin delivery device, which integrates H2O2 …

Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 …

TT Ly, JA Nicholas, A Retterath, EM Lim, EA Davis… - Jama, 2013 - jamanetwork.com
Importance Hypoglycemia is a critical obstacle to the care of patients with type 1 diabetes.
Sensor-augmented insulin pump with automated low-glucose insulin suspension has the …

Recovery of hypoglycemia awareness in long-standing type 1 diabetes: a multicenter 2× 2 factorial randomized controlled trial comparing insulin pump with multiple …

SA Little, L Leelarathna, E Walkinshaw, HK Tan… - Diabetes …, 2014 - Am Diabetes Assoc
OBJECTIVE To determine whether impaired awareness of hypoglycemia (IAH) can be
improved and severe hypoglycemia (SH) prevented in type 1 diabetes, we compared an …

Assessing sensor accuracy for non-adjunct use of continuous glucose monitoring

BP Kovatchev, SD Patek, EA Ortiz… - Diabetes technology & …, 2015 - liebertpub.com
Background: The level of continuous glucose monitoring (CGM) accuracy needed for insulin
dosing using sensor values (ie, the level of accuracy permitting non-adjunct CGM use) is a …

Real-time continuous glucose monitoring in type 1 diabetes: a qualitative framework analysis of patient narratives

JC Pickup, M Ford Holloway, K Samsi - Diabetes care, 2015 - Am Diabetes Assoc
OBJECTIVE This study analyzed narratives about experiences of real-time continuous
glucose monitoring (CGM) in people with type 1 diabetes. RESEARCH DESIGN AND …