Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

Despite improvements in modern cardiovascular therapy, the morbidity and mortality of
ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and …

Myocardial infarction (MI) has been considered as the leading cause of cardiovascular-
related deaths worldwide. Although traditional therapeutic agents including various …

Rationale: Despite 4 decades of intense effort and substantial financial investment, the
cardioprotection field has failed to deliver a single drug that effectively reduces myocardial …

Significance: Risk factors in the environment such as air pollution and traffic noise contribute
to the development of chronic noncommunicable diseases. Recent Advances …

Ischaemia/reperfusion (I/R) injury of the heart represents a major health burden mainly
associated with acute coronary syndromes. While timely coronary reperfusion has become …

Following a period of ischemia (local restriction of blood supply to a tissue), the restoration of
blood supply to the affected area causes significant tissue damage. This is known as …