Towards clinical translation of FLASH radiotherapy

MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …

Ultra-high dose rate (FLASH) radiotherapy: Silver bullet or fool's gold?

JD Wilson, EM Hammond, GS Higgins… - Frontiers in …, 2020 - frontiersin.org
Radiotherapy is a cornerstone of both curative and palliative cancer care. However,
radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be …

FLASH radiotherapy: current knowledge and future insights using proton-beam therapy

JR Hughes, JL Parsons - International journal of molecular sciences, 2020 - mdpi.com
FLASH radiotherapy is the delivery of ultra-high dose rate radiation several orders of
magnitude higher than what is currently used in conventional clinical radiotherapy, and has …

Tumour irradiation in mice with a laser-accelerated proton beam

F Kroll, FE Brack, C Bernert, S Bock, E Bodenstein… - Nature Physics, 2022 - nature.com
Recent oncological studies identified beneficial properties of radiation applied at ultrahigh
dose rates, several orders of magnitude higher than the clinical standard of the order of Gy …

Hypofractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice

P Montay-Gruel, MM Acharya, P Gonçalves Jorge… - Clinical Cancer …, 2021 - AACR
Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …

Ultra‐high dose rate dosimetry: challenges and opportunities for FLASH radiation therapy

F Romano, C Bailat, PG Jorge, MLF Lerch… - Medical …, 2022 - Wiley Online Library
The clinical translation of FLASH radiotherapy (RT) requires challenges related to dosimetry
and beam monitoring of ultra‐high dose rate (UHDR) beams to be addressed. Detectors …

Biological benefits of ultra-high dose rate FLASH radiotherapy: sleeping beauty awoken

MC Vozenin, JH Hendry, CL Limoli - Clinical oncology, 2019 - Elsevier
Abstract FLASH radiotherapy (FLASH-RT) is a technology that could modify the way
radiotherapy is delivered in the future. This technique involves the ultra-fast delivery of …

Treatment of a first patient with FLASH-radiotherapy

J Bourhis, WJ Sozzi, PG Jorge, O Gaide, C Bailat… - Radiotherapy and …, 2019 - Elsevier
Background When compared to conventional radiotherapy (RT) in pre-clinical studies,
FLASH-RT was shown to reproducibly spare normal tissues, while preserving the anti-tumor …

Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species

P Montay-Gruel, MM Acharya… - Proceedings of the …, 2019 - National Acad Sciences
Here, we highlight the potential translational benefits of delivering FLASH radiotherapy
using ultra-high dose rates (> 100 Gy⋅ s− 1). Compared with conventional dose-rate …

Physics and biology of ultrahigh dose-rate (FLASH) radiotherapy: a topical review

N Esplen, MS Mendonca… - Physics in Medicine & …, 2020 - iopscience.iop.org
Ultrahigh dose-rate radiotherapy (RT), or'FLASH'therapy, has gained significant momentum
following various in vivo studies published since 2014 which have demonstrated a reduction …