Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …

Methods for preparing high-resolution spatial arrays

FA Bava - US Patent 12,110,541, 2024 - Google Patents
Provided herein are methods of preparing a spatial array and methods for associating
specific sample analytes with spatial locations in the spatial array. Provided herein are …

Methods for synthesizing pools of probes

Y Wang, K Jones, RJ Sapolsky - US Patent 8,759,036, 2014 - Google Patents
Compositions, methods and kits are disclosed for synthesiz ing and amplifying pools of
probes using precursor oligo nucleotides. In some aspects the precursor is amplified and …

Increasing efficiency of spatial analysis in a biological sample

FA Bava - US Patent 11,732,300, 2023 - Google Patents
Disclosed herein are methods of amplifying an analyte in a biological sample using a
bridging oligonucleotide that hybridizes to a captured analyte. The methods disclosed …

Increasing capture efficiency of spatial assays

FA Bava - US Patent 11,898,205, 2024 - Google Patents
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-
oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo …

Methods for printing cells and generating arrays of barcoded cells

R Bharadwaj - US Patent 11,702,693, 2023 - Google Patents
US11702693B2 - Methods for printing cells and generating arrays of barcoded cells -
Google Patents US11702693B2 - Methods for printing cells and generating arrays of …

Generating capture probes for spatial analysis

Y Yin, EPR Iyer, Z Bent, S Giacomello… - US Patent …, 2023 - Google Patents
2021-06-10 Assigned to 10X GENOMICS, INC. reassignment 10X GENOMICS, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

Spatial assays with perturbed cells

EPR Iyer - US Patent 11,732,299, 2023 - Google Patents
US11732299B2 - Spatial assays with perturbed cells - Google Patents US11732299B2 -
Spatial assays with perturbed cells - Google Patents Spatial assays with perturbed cells Info …

Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
Extended European Search Report in European Appln. No. 21164322. 6, dated Sep. 6,
2021, 5 pages. Fu et al.,“Repeat subtraction-mediated sequence capture from a complex …

Methods for spatial analysis using RNA-templated ligation

JM Chell, M Stoeckius, J Alles, CJ Gallant… - US Patent …, 2022 - Google Patents
US11505828B2 - Methods for spatial analysis using RNA-templated ligation - Google
Patents US11505828B2 - Methods for spatial analysis using RNA-templated ligation …