A central challenge in evolutionary biology is to identify genes underlying ecologically
important traits and describe the fitness consequences of naturally occurring variation at …

Genomic studies of natural variation in model organisms provide a bridge between
molecular analyses of gene function and evolutionary investigations of adaptation and …

Drosophila melanogaster has played a pivotal role in the development of modern population
genetics. However, many basic questions regarding the demographic and adaptive history …

This report of independent genome sequences of two natural populations of Drosophila
melanogaster (37 from North America and 6 from Africa) provides unique insight into forces …

Molecular population genetics aims to explain genetic variation and molecular evolution
from population genetics principles. The field was born 50 years ago with the first measures …

In the classical model of molecular adaptation, a favored allele derives from a single
mutational origin. This ignores that beneficial alleles can enter a population recurrently …

An important goal of population genetics is to determine the forces that have shaped the
pattern of genetic variation in natural populations. We developed a maximum likelihood …

The beneficial substitution of an allele shapes patterns of genetic variation at linked sites.
Thus, in principle, adaptations can be mapped by looking for the signature of directional …

The role of positive darwinian selection in evolution at the molecular level has been keenly
debated for many years, with little resolution. However, a recent increase in DNA sequence …

Polymorphism data can be used to identify loci at which a beneficial allele has recently gone
to fixation, given that an accurate description of the signature of selection is available. In the …