Synthesis of oxa-, aza-and thia-bowls and cages
SJ Gharpure, SK Porwal - Organic Preparations and Procedures …, 2013 - Taylor & Francis
Synthesis of strained organic molecules has been a topic of interest amongst synthetic and
theoretical chemists over the past several years. 1–7 Whereas majority of the early efforts in …
theoretical chemists over the past several years. 1–7 Whereas majority of the early efforts in …
Non-B HIV-1 subtypes in sub-Saharan Africa: impact of subtype on protease inhibitor efficacy
Abstract In 2012, 25 million people [71% of global human immunodeficiency virus (HIV)
infection] were estimated to be living with HIV in sub-Saharan Africa. Of these, approximately …
infection] were estimated to be living with HIV in sub-Saharan Africa. Of these, approximately …
Open and rearranged norbornane derived polycyclic cage molecules as potential neuroprotective agents through attenuation of MPP+-and calcium overload-induced …
The neuroprotective effects of closed polycyclic cage molecules such as NGP1-01,
memantine and amantadine have been extensively explored. These effects are mostly …
memantine and amantadine have been extensively explored. These effects are mostly …
Pentacyclo-undecane derived cyclic tetra-amines: Synthesis and evaluation as potent anti-tuberculosis agents
OK Onajole, K Govender, P Govender… - European journal of …, 2009 - Elsevier
As part of an ongoing effort to develop highly potent anti-tuberculosis agents, fourteen
pentacyclo-undecane (PCU) tetra-amine compounds were synthesized and screened for …
pentacyclo-undecane (PCU) tetra-amine compounds were synthesized and screened for …
Novel polycyclic 'cage'-1, 2-diamines as potential anti-tuberculosis agents
OK Onajole, Y Coovadia, HG Kruger… - European journal of …, 2012 - Elsevier
A series of polycyclic 'cage'derivatives of N-geranyl-1, 2 diamines were synthesized and
screened for their anti-mycobacterial activity against H37Rv, multidrug resistant (MDR) and …
screened for their anti-mycobacterial activity against H37Rv, multidrug resistant (MDR) and …
Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease
MM Makatini, K Petzold, SN Sriharsha… - Bioorganic & medicinal …, 2011 - Elsevier
In this study, we present the first account of pentacycloundecane (PCU) peptide based HIV-
protease inhibitors. The inhibitor exhibiting the highest activity made use of a natural HIV …
protease inhibitors. The inhibitor exhibiting the highest activity made use of a natural HIV …
Photochemically Driven Tandem Process in the Construction of a Biscyclopropylcage from 2,5-Dimethoxy-p-benzoquinone and Terminal Acetylenes
J Álvarez-García, V Rubio-Pisabarro… - Organic …, 2020 - ACS Publications
A photochemical two-step one-pot synthesis of novel biscyclopropyl-box-shaped
compounds via the reaction of 2, 5-dimethoxy-para-benzoquinone and monosubstituted …
compounds via the reaction of 2, 5-dimethoxy-para-benzoquinone and monosubstituted …
Divergent syntheses of (−)-carvone-derived dimers
JJ Liu, BQ Zhang, K She, J Ran, HF Li, HS Wang… - Tetrahedron, 2024 - Elsevier
A series of diterpene-type compounds were synthesized starting from commercially
available (−)-carvone. The Michael reaction of (−)-carvone itself delivered four …
available (−)-carvone. The Michael reaction of (−)-carvone itself delivered four …
Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease …
Novel peptides incorporating the PCU derived hydroxy acid (5-hydroxy-4-oxahexacyclo [5.4.
1.02, 6.03, 10.05, 9.08, 11] dodecane) were synthesized and their activity against the …
1.02, 6.03, 10.05, 9.08, 11] dodecane) were synthesized and their activity against the …
Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors
In this study, eight non-natural peptides and peptoids incorporating the pentacycloundecane
(PCU) lactam were designed and synthesized as potential inhibitors of the wild type C-SA …
(PCU) lactam were designed and synthesized as potential inhibitors of the wild type C-SA …