Pharmacokinetics and pharmacodynamics of cannabinoids

F Grotenhermen - Clinical pharmacokinetics, 2003 - Springer
Abstract Δ 9-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects
caused by the consumption of cannabis, both the marijuana-like action and the medicinal …

[PDF][PDF] Adverse effects of cannabis and cannabinoids.

CH Ashton - British Journal of anaesthesia, 1999 - mybestbudca.com
The use of cannabis for both recreational and medicinal purposes dates back for thousands
of years. 15 91 It is perceived widely by recreational users as a harmless drug, a view …

Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana

RS Niedbala, KW Kardos, DF Fritch… - Journal of Analytical …, 2001 - academic.oup.com
We compared oral fluid testing to urine testing in subjects who were administered single
doses of marijuana by smoked and oral routes. Oral fluid specimens were collected with the …

Abstinence symptoms following oral THC administration to humans

M Haney, AS Ward, SD Comer, RW Foltin… - …, 1999 - Springer
Symptoms of dependence and withdrawal after the frequent administration of high doses
(210 mg/day) of oral Δ 9-tetrahydrocannabinol (THC) have been reported, yet little is known …

Cannabinoids

F Grotenhermen - Current Drug Targets-CNS & Neurological …, 2005 - ingentaconnect.com
Since the discovery of an endogenous cannabinoid system, research into the pharmacology
and therapeutic potential of cannabinoids has steadily increased. Two subtypes of G-protein …

Sex differences in the subjective effects of oral Δ9-THC in cannabis users

JS Fogel, TH Kelly, PM Westgate, JA Lile - Pharmacology Biochemistry and …, 2017 - Elsevier
Previous studies suggest that there are sex differences in endocannabinoid function and the
response to exogenous cannabinoids, though data from clinical studies comparing acute …

Depot naltrexone: long-lasting antagonism of the effects of heroin in humans

SD Comer, ED Collins, HD Kleber, ES Nuwayser… - …, 2002 - Springer
Rationale: Naltrexone, an opioid antagonist, is currently approved as a treatment for heroin
dependence. However, naltrexone is generally not well accepted by patients, and …

Comparison of smoked marijuana and oral Δ9-tetrahydrocannabinol in humans

CL Hart, AS Ward, M Haney, SD Comer, RW Foltin… - …, 2002 - Springer
Rationale. Although smoked marijuana contains at least 60 cannabinoids, Δ 9-
tetrahydrocannabinol (Δ 9-THC) is presumed to be the cannabinoid primarily responsible for …

[PDF][PDF] Cannabis(Marijuana)- Effects on Human Behavior and Performance

MA Huestis - Forensic Science Review, 2002 - flugmedizin.at
Cannabis is one of the oldest and most commonly abused drugs in the world. Recently,
tremendous advances have been made in our understanding of the endogenous …

The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance

BY Silber, RJ Croft, K Papafotiou, C Stough - Psychopharmacology, 2006 - Springer
Rationale It is not clear how the deleterious effects of amphetamines on driving performance
are mediated in terms of select cognitive processes. Objectives The current three separate …