The phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS) is found
only in bacteria, where it catalyzes the transport and phosphorylation of numerous …

Carbon catabolite repression (CCR) by transcriptional regulators follows different
mechanisms in gram-positive and gram-negative bacteria. In gram-positive bacteria, CcpA …

CAPRI is a communitywide experiment to assess the capacity of protein‐docking methods to
predict protein–protein interactions. Nineteen groups participated in rounds 1 and 2 of …

This article is dedicated to the memory of Michael G. Rossmann. Dating back to the last
universal common ancestor, P-loop NTPases and Rossmanns comprise the most ubiquitous …

Reversible protein phosphorylation is a major mechanism in the regulation of fundamental
signalling events in all living organisms. Bacteria have been shown to possess a versatile …

Structural biology can provide three-dimensional structures for proteins of unknown function.
When sequence or structure comparisons fail to suggest a function, insights can come from …

The first clearly established example of Ser/Thr/Tyr phosphorylation of a bacterial protein
was isocitrate dehydrogenase. In 1979, 25 years after the discovery of protein …

Homo-oligomeric protein assemblies are known to participate in dynamic association/
disassociation equilibria under native conditions, thus creating an equilibrium of assembly …

Classic models for the allosteric regulation of protein function consider an equilibrium
among protein structures of constant oligomeric multiplicity. The morpheein (mor-phee'-in) …

In most Gram-positive bacteria, serine-46-phosphorylated HPr (P-Ser-HPr) controls the
expression of numerous catabolic genes (≈ 10% of their genome) by acting as catabolite …