Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
The Tribbles (TRIB) pseudokinases control multiple aspects of eukaryotic cell biology and
evolved unique features distinguishing them from all other protein kinases. The atypical …
evolved unique features distinguishing them from all other protein kinases. The atypical …
The genetic interactions between non-alcoholic fatty liver disease and cardiovascular diseases
The ongoing debate on whether non-alcoholic fatty liver disease (NAFLD) is an active
contributor or an innocent bystander in the development of cardiovascular disease (CVD) …
contributor or an innocent bystander in the development of cardiovascular disease (CVD) …
Advances in genetic variation in metabolism-related fatty liver disease
F Shi, M Zhao, S Zheng, L Zheng, H Wang - Frontiers in Genetics, 2023 - frontiersin.org
Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver
disease in the world. Its pathogenesis is influenced by both environmental and genetic …
disease in the world. Its pathogenesis is influenced by both environmental and genetic …
Pseudokinases: update on their functions and evaluation as new drug targets
The pseudokinase complement of the human kinase superfamily consists of approximately
60 signaling proteins, which lacks one or more of the amino acids typically required to …
60 signaling proteins, which lacks one or more of the amino acids typically required to …
The critical role of TRIB2 in cancer and therapy resistance
V Mayoral-Varo, L Jiménez, W Link - Cancers, 2021 - mdpi.com
Simple Summary The Tribbles proteins are members of CAMK Ser/Thr protein kinase family.
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …
They are evolutionary conserved pseudokinases found in most tissues of eukaryotic …
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic
variation underlying human traits. Here we apply genotype imputation based on whole …
variation underlying human traits. Here we apply genotype imputation based on whole …
Mangiferin modulation of metabolism and metabolic syndrome
EV Fomenko, Y Chi - BioFactors, 2016 - Wiley Online Library
The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and
diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt …
diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt …
Genomic and functional regulation of TRIB1 contributes to prostate cancer pathogenesis
P Shahrouzi, I Astobiza, AR Cortazar, V Torrano… - Cancers, 2020 - mdpi.com
Prostate cancer is the most frequent malignancy in European men and the second
worldwide. One of the major oncogenic events in this disease includes amplification of the …
worldwide. One of the major oncogenic events in this disease includes amplification of the …
TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese …
Q Liu, SS Liu, ZZ Zhao, BT Zhao, SX Du… - Lipids in Health and …, 2019 - Springer
Background Present evidences suggested that TRIB1 rs17321515 polymorphism was tightly
associated with the increased risk of NAFLD and CHD. CHD is one of the main …
associated with the increased risk of NAFLD and CHD. CHD is one of the main …
TRIB1 and TRPS1 variants, G × G and G × E interactions on serum lipid levels, the risk of coronary heart disease and ischemic stroke
QH Zhang, RX Yin, WX Chen, XL Cao, JZ Wu - Scientific Reports, 2019 - nature.com
This study aimed to assess the association of the tribbles pseudokinase 1 (TRIB1) and
transcriptional repressor GATA binding 1 (TRPS1) single nucleotide polymorphisms (SNPs) …
transcriptional repressor GATA binding 1 (TRPS1) single nucleotide polymorphisms (SNPs) …