[HTML][HTML] Cellular metabolism: A fundamental component of degeneration in the nervous system
K Maiese - Biomolecules, 2023 - mdpi.com
It is estimated that, at minimum, 500 million individuals suffer from cellular metabolic
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …
dysfunction, such as diabetes mellitus (DM), throughout the world. Even more concerning is …
Role of estrogen in women's Alzheimer's disease risk as modified by APOE
AC Valencia‐Olvera… - Journal of …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is characterized by numerous sexual dimorphisms that impact the
development, progression, and probably the strategies to prevent and treat the most …
development, progression, and probably the strategies to prevent and treat the most …
[HTML][HTML] Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Background Altered intestinal microbiota composition in later life is associated with
inflammaging, declining tissue function, and increased susceptibility to age-associated …
inflammaging, declining tissue function, and increased susceptibility to age-associated …
[HTML][HTML] Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and …
MG Pontifex, E Connell, G Le Gall, L Pourtau… - Food & Function, 2022 - pubs.rsc.org
Treatment of anxiety and depression predominantly centres around pharmacological
interventions, which have faced criticism for their associated side effects, lack of efficacy and …
interventions, which have faced criticism for their associated side effects, lack of efficacy and …
[HTML][HTML] The metabolic basis for nervous system dysfunction in alzheimer's disease, parkinson's disease, and huntington's disease
K Maiese - Current neurovascular research, 2023 - ncbi.nlm.nih.gov
Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …
greatest impact on both central and peripheral nervous systems. Current available …
[HTML][HTML] The impact of aging and oxidative stress in metabolic and nervous system disorders: programmed cell death and molecular signal transduction crosstalk
K Maiese - Frontiers in immunology, 2023 - frontiersin.org
Life expectancy is increasing throughout the world and coincides with a rise in non-
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …
communicable diseases (NCDs), especially for metabolic disease that includes diabetes …
[HTML][HTML] Sex differences in metabolic indices and chronic neuroinflammation in response to prolonged high-fat diet in ApoE4 knock-in mice
Late-onset Alzheimer's disease (LOAD) likely results from combinations of risk factors that
include both genetic predisposition and modifiable lifestyle factors. The E4 allele of …
include both genetic predisposition and modifiable lifestyle factors. The E4 allele of …
Fish, n-3 fatty acids, cognition and dementia risk: not just a fishy tale
RNM Saleh, AM Minihane - Proceedings of the Nutrition Society, 2022 - cambridge.org
With growing and ageing populations, the incidence of dementia is expected to triple
globally by 2050. In the absence of effective drugs to treat or reverse the syndrome, dietary …
globally by 2050. In the absence of effective drugs to treat or reverse the syndrome, dietary …
[HTML][HTML] The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer's disease
TE Swingler, L Niu, MG Pontifex, D Vauzour… - International journal of …, 2022 - mdpi.com
The complete molecular mechanisms underlying the pathophysiology of Alzheimer's
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
[HTML][HTML] An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases
Z Wu, J Sun, Z Liao, J Qiao, C Chen, C Ling… - Frontiers in …, 2022 - frontiersin.org
Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that
activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP …
activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP …