Epstein–Barr virus and multiple sclerosis

SS Soldan, PM Lieberman - Nature Reviews Microbiology, 2023 - nature.com
Epstein–Barr virus (EBV) is a ubiquitous human lymphotropic herpesvirus with a well-
established causal role in several cancers. Recent studies have provided compelling …

Epstein–Barr virus as a leading cause of multiple sclerosis: mechanisms and implications

K Bjornevik, C Münz, JI Cohen, A Ascherio - Nature Reviews Neurology, 2023 - nature.com
Epidemiological studies have provided compelling evidence that multiple sclerosis (MS) is a
rare complication of infection with the Epstein–Barr virus (EBV), a herpesvirus that infects …

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

TV Lanz, RC Brewer, PP Ho, JS Moon, KM Jude… - Nature, 2022 - nature.com
Multiple sclerosis (MS) is a heterogenous autoimmune disease in which autoreactive
lymphocytes attack the myelin sheath of the central nervous system. B lymphocytes in the …

Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis

OG Thomas, M Bronge, K Tengvall, B Akpinar… - Science …, 2023 - science.org
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which
Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between …

The role of viral infections in the onset of autoimmune diseases

B Sundaresan, F Shirafkan, K Ripperger, K Rattay - Viruses, 2023 - mdpi.com
Autoimmune diseases (AIDs) are the consequence of a breach in immune tolerance,
leading to the inability to sufficiently differentiate between self and non-self. Immune …

Epstein-Barr virus and multiple sclerosis

WH Robinson, L Steinman - Science, 2022 - science.org
Infection with the Epstein-Barr virus (EBV) has long been postulated to trigger multiple
sclerosis (MS). Prior analyses demonstrated increased serum antibodies to EBV in∼ 99.5 …

Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

HLA-DR15 molecules jointly shape an autoreactive T cell repertoire in multiple sclerosis

J Wang, I Jelcic, L Mühlenbruch, V Haunerdinger… - Cell, 2020 - cell.com
The HLA-DR15 haplotype is the strongest genetic risk factor for multiple sclerosis (MS), but
our understanding of how it contributes to MS is limited. Because autoreactive CD4+ T cells …

Human coronary plaque T cells are clonal and cross-react to virus and self

RR Chowdhury, J D'Addabbo, X Huang… - Circulation …, 2022 - Am Heart Assoc
Background: Coronary artery disease is an incurable, life-threatening disease that was once
considered primarily a disorder of lipid deposition. Coronary artery disease is now also …

Molecular mimicry in multisystem inflammatory syndrome in children

A Bodansky, RC Mettelman, JJ Sabatino Jr… - Nature, 2024 - nature.com
Multisystem inflammatory syndrome in children (MIS-C) is a severe, post-infectious sequela
of SARS-CoV-2 infection,, yet the pathophysiological mechanism connecting the infection to …