The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

One of the open questions in RAS biology is the existence of RAS dimers and their role in
RAF dimerization and activation. The idea of RAS dimers arose from the discovery that RAF …

Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

The protein K-Ras functions as a molecular switch in signaling pathways regulating cell
growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated …

Here we discuss approaches to K-Ras inhibition and drug resistance scenarios. A
breakthrough offered a covalent drug against K-RasG12C. Subsequent innovations …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

DIRAS3 is an imprinted tumor suppressor gene that encodes a 26 kDa GTPase with 60%
amino acid homology to RAS, but with a distinctive 34 amino acid N-terminal extension …

Ovarian cancer is one of the most common causes of death in women as survival is highly
dependent on the stage of the disease. Ovarian cancer is typically diagnosed in the late …

Abstract RAS/RAF/MEK/ERK signaling pathway is one of the most important pathways of
Mitogen-activated protein kinases (MAPK), which widely participate in regulating cell …

Abstract Self‐assemblies (ie, nanoclusters) of the RAS GTPase on the membrane act as
scaffolds that activate downstream RAF kinases and drive MAPK signaling for cell …