Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the
interface of cellular redox and intermediary metabolism. Nrf2 target genes encode …

Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

The Nrf2-Keap1-ARE pathway is the principal regulator of antioxidant and phase II
detoxification genes. Its activation increases the expression of antioxidant and cytoprotective …

Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …

Astrocytes are dynamic cells that maintain brain homeostasis, regulate neurotransmitter
systems, and process synaptic information, energy metabolism, antioxidant defenses, and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, for which no disease‐
modifying therapies are available to date. Although understanding of the precise aetiology of …

With the extension of life span in recent decades, there is an increasing burden of late-onset
neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative …

Age-related macular degeneration (AMD) is a mounting cause of loss of sight in the elderly
in the developed countries, a trend enhanced by the continual ageing of the population …

Oxidative stress and inflammation have long been recognized to contribute to Parkinson's
disease (PD), a common movement disorder characterized by the selective loss of midbrain …