Hydrogel microparticles for biomedical applications
Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the
therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and …
therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and …
Intra-articular targeting of nanomaterials for the treatment of osteoarthritis
Osteoarthritis is a prevalent and debilitating disease that involves pathological contributions
from numerous joint tissues and cells. The joint is a challenging arena for drug delivery …
from numerous joint tissues and cells. The joint is a challenging arena for drug delivery …
Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress
Oxidative stress has been implicated in the pathogenesis of osteoarthritis and has become
an important therapeutic target. Investigations of various antioxidant supplements, reactive …
an important therapeutic target. Investigations of various antioxidant supplements, reactive …
Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy
Oxidative stress and the reactive oxygen species (ROS) have important roles in
osteoarthritis (OA) development and progression. Scavenging ROS by exogenous …
osteoarthritis (OA) development and progression. Scavenging ROS by exogenous …
Recent advances in intra-articular drug delivery systems for osteoarthritis therapy
P Maudens, O Jordan, E Allémann - Drug discovery today, 2018 - Elsevier
Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …
Cartilage-targeting and dual MMP-13/pH responsive theranostic nanoprobes for osteoarthritis imaging and precision therapy
H Chen, Z Qin, J Zhao, Y He, E Ren, Y Zhu, G Liu… - Biomaterials, 2019 - Elsevier
Osteoarthritis (OA) microenvironment is marked by matrix metalloproteinases-13 (MMP-13)
overexpression and weak acidity, making it possible to develop dual-stimuli responsive …
overexpression and weak acidity, making it possible to develop dual-stimuli responsive …
Bioactive factors for cartilage repair and regeneration: improving delivery, retention, and activity
Articular cartilage is a remarkable tissue whose sophisticated composition and architecture
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
allow it to withstand complex stresses within the joint. Once injured, cartilage lacks the …
Chondroitin sulfate microspheres anchored with drug-loaded liposomes play a dual antioxidant role in the treatment of osteoarthritis
Reactive oxygen species (ROS) play a critical role in the pathogenesis of osteoarthritis. The
injection of a single antioxidant drug is characterized by low drug utilization and short …
injection of a single antioxidant drug is characterized by low drug utilization and short …
Knee osteoarthritis therapy: recent advances in intra-articular drug delivery systems
L Ma, X Zheng, R Lin, ARJ Sun, J Song… - Drug design …, 2023 - Taylor & Francis
Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …
Intra-articular drug delivery systems for joint diseases
Highlights•Focus on disease-modifying approaches for intra-articular drug
delivery.•Polymeric particles as platforms for sustained and controlled drug release.•In vivo …
delivery.•Polymeric particles as platforms for sustained and controlled drug release.•In vivo …