Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

In recent years, there has been an explosion of interest in how fibroblasts initiate, sustain,
and resolve inflammation across disease states. Fibroblasts contain heterogeneous subsets …

Fibroblastic stromal cells are as diverse, in origin and function, as the niches they fashion in
the mammalian body. This cellular variety impacts the spectrum of responses elicited by the …

Diets high in cholesterol alter intestinal immunity. Here, we examined how the cholesterol
metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice …

Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive
compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by …

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral
immunity with B cell priming and memory maintenance being orchestrated across lymphoid …

Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in
discrete microenvironments of lymphoid organs. Despite their important role in steering …

Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …

Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs
that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to …

Single-cell technologies have recently allowed the identification of multiple lymphatic
endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph …