Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

Introduction: High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that
promotes inflammation when released extracellularly after cellular activation, stress …

The most common forms of acquired epilepsies arise following acute brain insults such as
traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for …

The epilepsies are a heterogeneous group of disorders characterized by the propensity to
experience spontaneous recurrent seizures. Epilepsies can be genetic or acquired, and the …

Accumulating evidence indicates an important pathophysiological role of brain inflammation
in epilepsy. In this review, we will provide an update of specific inflammatory pathways that …

Neurological disorders represent a great challenge and are the leading cause of death and
disability globally. Although numerous complicated mechanisms are involved in the …

High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic
tissues or secreted actively by stressed cells. Extracellular HMGB1 is a typical damage …

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

Posttraumatic epilepsy (PTE) is a prevalent type of acquired epilepsy secondary to traumatic
brain injury, and is characterized by repeated seizures. Traditional antiepileptic drugs have …