The role of smoking in the mechanisms of development of chronic obstructive pulmonary disease and atherosclerosis

S Kotlyarov - International Journal of Molecular Sciences, 2023 - mdpi.com
Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD) and
atherosclerotic cardiovascular disease (ASCVD). These diseases share common …

[HTML][HTML] Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice

M Seimetz, N Parajuli, A Pichl, F Veit, G Kwapiszewska… - Cell, 2011 - cell.com
Chronic obstructive pulmonary disease (COPD) is one of the most common causes of death
worldwide. We report in an emphysema model of mice chronically exposed to tobacco …

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

H Yao, I Rahman - Toxicology and applied pharmacology, 2011 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …

Group 3 pulmonary hypertension: from bench to bedside

N Singh, P Dorfmüller, OA Shlobin… - Circulation …, 2022 - Am Heart Assoc
Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3
PH in the most recent classification system. Prevalence of these diseases is increasing over …

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

CE Green, AM Turner - Respiratory research, 2017 - Springer
COPD and asthma are important chronic inflammatory disorders with a high associated
morbidity. Much research has concentrated on the role of inflammatory cells, such as the …

Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases

IK Sundar, H Yao, I Rahman - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: Chronic obstructive pulmonary disease (COPD) is predominantly a tobacco
smoke-triggered disease with features of chronic low-grade systemic inflammation and …

Animal models of pulmonary hypertension: Getting to the heart of the problem

JP Dignam, TE Scott, BK Kemp‐Harper… - British Journal of …, 2022 - Wiley Online Library
Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

Pulmonary hypertension in chronic obstructive pulmonary disease

M Gredic, I Blanco, G Kovacs, Z Helyes… - British journal of …, 2021 - Wiley Online Library
Even mild pulmonary hypertension (PH) is associated with increased mortality and morbidity
in patients with chronic obstructive pulmonary disease (COPD). However, the underlying …

Animal models and mechanisms of tobacco smoke-induced chronic obstructive pulmonary disease (COPD)

P Upadhyay, CW Wu, A Pham, AA Zeki… - Journal of Toxicology …, 2023 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death
worldwide, and its global health burden is increasing. COPD is characterized by …

Effects of cigarette smoke on pulmonary endothelial cells

Q Lu, E Gottlieb, S Rounds - American Journal of …, 2018 - journals.physiology.org
Cigarette smoking is the leading cause of preventable disease and death in the United
States. Cardiovascular comorbidities associated with both active and secondhand cigarette …