Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted
into motile cells, multicellular organisms would be incapable of getting past the blastula …

The Snail superfamily of zinc-finger transcription factors is involved in processes that imply
pronounced cell movements, both during embryonic development and in the acquisition of …

Transcriptional repression mechanisms have emerged as one of the crucial processes for
the downregulation of E-cadherin expression during development and tumour progression …

The aggressive clinical behavior of melanoma suggests that the developmental origins of
melanocytes in the neural crest might be relevant to their metastatic propensity. Here we …

The ancestors of modern Metazoa were constructed in large part by the foldings and
distortions of two-dimensional sheets of epithelial cells. This changed∼ 600 million years …

The conversion of stationary epithelial cells into migratory, invasive cells is important for
normal embryonic development and tumour metastasis. Border-cell migration in the ovary of …

The bones in your face, the pigment in your skin and the neural circuitry that controls your
digestive tract have one thing in common: they are all derived from neural crest cells. The …

The neural crest is a multipotent population of migratory cells unique to the vertebrate
embryo. Neural crest arises at the lateral edge of the neural plate and migrates throughout …

Current cancer therapies are highly toxic and often nonspecific. A potentially less toxic
approach to treating this prevalent disease employs agents that modify cancer cell …

The SOX family of transcription factors has been implicated in cell fate specification during
embryogenesis. One member of this family, Sox9, has been shown to regulate both …