Lower respiratory tract infections are associated with high morbidity and mortality and
significant clinical harm. Due to the limited ability of traditional pathogen detection methods …

Biofilms are population of cells growing in a coordinated manner and exhibiting resistance
towards hostile environments. The infections associated with biofilms are difficult to control …

Next-generation sequencing (NGS) workflows applied to bronchoalveolar lavage (BAL) fluid
specimens could enhance the detection of respiratory pathogens, although optimal …

Many common pathogens are difficult or impossible to detect using conventional
microbiological tests. However, the rapid and untargeted nature of metagenomic next …

Objectives Identifying pathogens in patients with pulmonary infection (PI) has always been a
major challenge in medicine. Compared with sputum and throat swabs, bronchoalveolar …

Pneumonia is the leading cause of death in children; the pathogens are often difficult to
diagnose. In this study, the performance of metagenomic next-generation sequencing …

Metagenomic next-generation sequencing (mNGS) has been gradually applied to clinical
practice due to its unbiased characteristics of pathogen detection. However, its diagnostic …

Pathogen sequencing is a transformational proposition for microbiology laboratories and
their infectious diseases, infection control, and public health partners. Healthcare systems …

Introduction This study aims to assess the value of metagenomic next-generation
sequencing (mNGS) of bronchoalveolar lavage fluid (BALF) in the diagnosis of …

Background Despite the obvious advantages of metagenomic next-generation sequencing
(mNGS) in etiological diagnosis of various infectious diseases, there are few reports on …