Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …

Proteases are important for multiple processes during malignant progression, including
tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor …

Fintech allows investors to explore previously unavailable investment opportunities; it
provides new return opportunities while also introducing new risks. The aim of this study is to …

BACKGROUND With the emergence of the tumor microenvironment as an essential
ingredient of cancer malignancy, therapies targeting the host compartment of tumors have …

Including the true tissue kallikrein KLK1, kallikrein-related peptidases (KLKs) represent a
family of fifteen mammalian serine proteases. While the physiological roles of several KLKs …

Rosacea is a common inflammatory facial dermatoses affecting primarily adults with fair
skin, although all skin types may be affected. The diagnostic term “rosacea” reflects a …

Systemic lupus erythematosus (SLE) is a systemic, autoimmune disease that can involve
virtually any organ of the body. Lupus nephritis (LN), the clinical manifestation of this …

Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the
largest protease group in humans and more generally in vertebrates. The prototypes …

Cancer is the second leading cause of death with 14 million new cases and 8.2 million
cancer-related deaths worldwide in 2012. Despite the progress made in cancer therapies …

Skin appearance is essential for self‐esteem and quality of life; consequently, skin care
products represent a huge market. In particular, cosmeceuticals constitute a hybrid category …